pharmaceutical chemistry

2 articles tagged “pharmaceutical chemistry”

Synthesis & Manufacturing

Peptide PTM: Phosphorylation & Glycosylation

When Frederick Banting's team discovered insulin in 1921, they faced an unexpected obstacle: the hormone degraded within hours, requiring multiple injections daily. Today, peptide post-translational modifications like phosphorylation and glycosylation offer a solution to this ancient stability probl

AdminUpdated Aug 410 min

Synthesis & Manufacturing

Peptide Oral vs Injection Delivery Comparison

In September 2019, the FDA approved oral semaglutide, marking the first successful oral GLP-1 peptide after four decades of failed attempts—a milestone that reveals why peptide oral bioavailability remains far more difficult to achieve than injection-based delivery.

AdminUpdated Jul 2810 min