drug design

2 articles tagged “drug design”

Peptide Mechanisms

Peptide Biased Signaling Selective Pathway Activation

Tirzepatide's approval in 2022 sparked quieter excitement among structural biologists studying peptide biased signaling—how a single receptor activates different cellular pathways depending on which molecule binds to it. The University of Michigan and Eli Lilly teams mapped the mechanism with unusua

AdminUpdated Aug 1410 min

Peptide Mechanisms

Peptide Cross-Reactivity: Off-Target Binding Guide

In May 2022, the FDA approved tirzepatide, a dual-receptor peptide built intentionally to bind two targets at once—but the mechanism behind unintended cross-reactivity in single-target designs remains poorly understood, raising questions about peptide specificity that have shadowed incretin research

AdminUpdated Aug 310 min