structural biology

2 articles tagged “structural biology”

Peptide Mechanisms

Peptide Biased Signaling Selective Pathway Activation

Tirzepatide's approval in 2022 sparked quieter excitement among structural biologists studying peptide biased signaling—how a single receptor activates different cellular pathways depending on which molecule binds to it. The University of Michigan and Eli Lilly teams mapped the mechanism with unusua

AdminUpdated Aug 1410 min

Peptide Mechanisms

Peptide Conformational Stability in 3D

Two peptides with identical amino acid sequences can behave as entirely different molecules depending on their three-dimensional structure—one binds its target receptor with precision while the other misses entirely, a geometric reality that determines whether peptide conformational stability transl

AdminUpdated Jul 3013 min