clinical trials

8 articles tagged “clinical trials”

Peptide Mechanisms

Peptide Tachyphylaxis: Receptor Tolerance Guide

In 2004, cultured cell studies revealed that GLP-1 receptors desensitize within hours of continuous exposure—a finding that should have foreclosed their use as durable therapeutics, yet animal models and clinical trials told a different story about peptide tachyphylaxis and long-term receptor tolera

AdminUpdated Aug 1810 min

NASH Fibrosis & Peptide Therapy

NASH Fibrosis Peptide Therapy Reversal

In March 2024, the FDA approved resmetirom for NASH, marking the first regulatory victory after two decades of failed Phase 3 trials—yet NASH fibrosis progression and peptide therapy's potential role in reversing scarring remain largely unexplored in clinical settings.

AdminUpdated Aug 119 min

Cognitive Health & Aging

GLP-1 Receptor Agonists and Brain Neuroprotection

In 2021, researchers at Lund University began testing exenatide, a GLP-1 receptor agonist, for potential neuroprotection in Parkinson's disease—a use far removed from its original approval for type 2 diabetes.

AdminUpdated Aug 19 min

Regulatory & Approval Status

Why BPC-157 Isn't FDA Approved Yet

After 30 years and 150 peer-reviewed publications, BPC-157 remains without FDA approval—a puzzle that reveals how regulatory pathways, funding constraints, and the absence of large-scale human trials can stall a compound indefinitely.

AdminUpdated Jul 2810 min

Clinical Evidence & Mechanisms

GHK-Cu Peptide: What the Science Actually Shows

GHK-Cu shows promise in lab research, but what does the actual clinical trial evidence reveal? Our comprehensive GHK-Cu clinical trial evidence review separates hype from science.

AdminUpdated Jul 2821 min

Clinical Trials & Research

Retatrutide HbA1c Reduction Diabetes Study

Discover how retatrutide's impressive mean body weight loss complements its potential in blood sugar control, supported by the latest retatrutide HbA1c reduction diabetes study, offering new hope for managing type 2 diabetes effectively.

AdminUpdated Jul 2813 min

Clinical Trials & Research

TRIUMPH Trial Retatrutide Phase 3 Obesity Study

Discover the groundbreaking TRIUMPH trial for retatrutide and its pivotal role in the phase 3 obesity journey towards FDA approval, revealing astonishing weight loss results and new hope for effective obesity treatments.

AdminUpdated Jul 2811 min

Clinical Trials & Research

Retatrutide NEJM 2023 Phase 2 Obesity Results

The retatrutide NEJM 2023 phase 2 obesity trial reveals groundbreaking weight loss results, with participants losing an average of 24.2% of their body weight — but what does the data truly convey about its potential in obesity treatment?

AdminUpdated Jul 2813 min